Issues on trade will always remain between friendly countries! US & Canada have always bickered over milk & cheese trade!!!
Strategically there's a lot of convergence between US and India! Bush/Obama pushed it, Jim Mattis took it forward; Bolton and Pompeo seem to be doing the same (Trump is an idiot, has no idea what he's doing or talking)
It's not only about trade, American intervention in countries which are trade partners of India will sour relationship for sure.
As for "convergence", even though I hate PRC even more after Azhar episode, China is more likely to be India's ally than US.
US is important because its a superpower. China is important because its actual trade partner. China right now is world's biggest factory from where India is buying and in future in its post industrial era, it will be world's biggest market where India will sell its stuff.
US comes in picture as India wants to emerge as another pole of world like US, Russia and China. But one of those poles is hostile to India and sits in India's immediate neighborhood.
US for its own security reasons, wants to subordinate India. But India stayed strategically autonomous and didn't become second class power like France, UK or Japan which ultimately sent America's "pivot to Asia" down the drain.
If India joins "First World" block (highly unlikely), its security will be risked facing direct hostilities from "Second World" in neighborhood. In case there is some sort of strategic bargaining between India & China leading to their alignment, US will lose importance in India's long term foreign policy.
In case India keeps balancing things and reamains a "Third World" country even as a pole of power like its doing today, impact of interests will turn US vitroilic and hostile to India gradually and eventually.
Believe me or not, I have seen Americans being hardcore nationalists day by day. They have insecurities of losing their dominance and they hate every country who has potential to do that.