The F-35A with max internal fuel is only 2200km range, combat radius only 1100km, Russian cruise missiles drop at over 3000km from their target. Without drop tanks it will never be able to intercept the Tu-160 much less chase it down. Once the missiles are dropped, the chances of stopping them drops to zero. The bomber must be intercepted before the launch point.
This is yet another reason why the F-35 cannot replace the F-22. It doesn't have the range, the supercruise speed or the ability to get there without drop tanks to make it an effective interceptor. In this mission it is a complete and total failure. Speaking of the UK's F-35Bs, that is the biggest joke of all.
Neither the F-22 nor Rafale with 3 EFTs nor any of the current 4th gen fighters with EFTs can intercept Tu-160 lunching Kh-55SM as that missile has a range of 3,000 km range if a TU-160 is able to find and out-of-reach launching position.
So your argument about F-35 is nonsense as it applies to all current fighters.
But you consider real-World scenarios where Tu-160s will opetatd from:
1. In Europe, I'm sure NATO has already some laid out a defensive strategy against it as early as the 1980s. But recently NATOs defenses has only gotten more robust with the addition of AEGIS ashore in Poland and Romania that can be equipped wiyh SM-6.
2. In Asia against Japanese targets their territories are close to each other. Unless Tu-160 lunches from within Russia then Japanese, US and Korean fighters can intercept it.
But granting that a TU-160 lunchesbits KH-55SM from its max range from deep in Russian territory then allied AEGIS systems both on ships and ashore will be the first line of defense. Then THAAD and Patriot.
Note that KH-55SM is an old cruise misdile that has been long known to American and allies. So they already have robust measutes to counter it.
3. Against the US mainland, well it'll escalate pretty quickly. I don't think Russia will do it. And if it does it then a Tu-160 then NORAD will take care of it.
So again, stop these nonsense. Neither Rafale with 3 EFTs and A2A weapons will be able to intercept a Tu-160 from 3000 kilometers away on a one-on-one scenario. Besides, Rafale under that load will not fly fast enough due to weight and drag penalties to get to station on time. A clean F-35 can fly faster.
More importantly, a cruise missile attack from Tu-160 from Russia will be a declaration of war and will most likely turn nuclear. So I don't think it's going to happen.
As I said yesterday, the Russians were simply out to get cheap propaganda tricks on the F-35.