Wuhan Coronavirus Thread

[Okabe Rintarou]

I am starting to believe this new strain is released as hit to impact Modi govt targeted towards Indian genetics, it is not spreading anywhere yet even after weeks

How would that even work? What trait of "Indian genetics" will the virus target. Not dismissive of your assertion, just genuinely curious.

 

[omaebakabaka]

Summary of this video:

The Indian Consul-General in Hong Kong asked the Chinese government to intervene and regulate prices of COVID-related supplies (such as O2 Concentrators). Someone asked chicom gobbels Hua Chunying about this.

She said "yes, all parties should work toward an open global supply chain."

And now the real translation: "Remove all the trade embargoes you placed on Chinese products since Galwan, and we'll think about regulating prices of COVID supplies."

Lol, our head in the sand....decades if short sighted policies by governments across the world in creating these deadly dependencies. And we wanted to push for kinetic war and blame modi? People have really short memories when things don't go their way

 

[omaebakabaka]

How would that even work? What trait of "Indian genetics" will the virus target. Not dismissive of your assertion, just genuinely curious.

There are several markers, considering Indians and South Asians have traits to develop diabetes and heart conditions and what not makes me believe these markers are researched by bat country and possibly soros labs, it is really very possible considering what monsanto and some other biotech companies like Moderna and Pfizer are capable of...

 

[Okabe Rintarou]

There are several markers, considering Indians and South Asians have traits to develop diabetes and heart conditions and what not makes me believe these markers are researched by bat country and possibly soros labs, it is really very possible considering what monsanto and some other biotech companies like Moderna and Pfizer are capable of...

So something like this? https://www.nature.com/articles/s41586-020-03065-y

 

[captscooby81]

Posting entire twitter thread done by someone with some good info

Recently various sources have pitched the Pfizer vaccine for India. This parlays the recent western ‘branding’ effort differentiating Pfizer, but it is known that this vaccine has some unique technical requirements. This thread analyzes the Pfizer logistics in depth.

Storage The vaccine must be stored at -60 to -80C, i.e. ultra low temp (ULT), much colder than normal freezer (-20C) or fridge (2 to 8C). Such storage systems are costly but cost depends on capacity. These have alarm systems to notify of failure or temperature fluctuations.

The Pfizer transport box shows ~5000 doses = 10L tray volume. It is packed with dry ice and can be transported for no more than 10 days unopened, 15 if dry ice recharged. Each pallet has IoT comm to notify Pfizer of problems: https://truckinginfo.com/10134508/vaccine-logistics-fleets-find-opportunity-in-crisis… https://bbc.com/news/technology-54889084…

The contents of each box must be moved into ULT storage in 2-5 minutes according to CDC guidelines. Not only must the vaccines not get too warm, but they must not get too cold either. This makes storage and transportation complicated: https://thehill.com/policy/healthcare/530510-us-officials-had-to-quarantine-and-return-pfizer-vaccine-doses-after-they…

A major hospital could hold several boxes worth of doses, but the ULT freezers cost between 3-5lakh (pretax) for small ones, up to 25 lakh for ~800L Stirling Ultracold freezers suited to large storage nodes. ULT freezers have high operating cost and require stable power.

Recently many high end hospitals were found lacking in on-premises O2 plant despite only 30-50L cost. This is generally useful and yet the cost could not be justified. How many hospitals will spend on specialized ULT storage ? https://theprint.in/theprint-essential/psa-oxygen-plants-the-cleaner-cheaper-tech-that-could-help-ease-indias-current-crisis/646934/…

In addition, an entire ULT infrastructure is needed. India has a vibrant cold chain infra but only for up to -25C needs, not ULT. The 28000-unit cold storage network used by Indian immunization programs support 2 to 8C storage. https://thefederal.com/uncategorized/indias-cold-chain-a-challenge-as-pfizer-makes-covid-vaccine-breakthrough/… https://gavi.org/vaccineswork/longest-mile-covid-19-vaccine-cold-chain…

Thawed vials can be kept in a fridge for 5 days. Once opened, each vial (5-6 doses) must be consumed within 6 hrs. Vials must be mixed with saline diluent beforehand. Moderna, J&J, Covaxin, Covishield, Sputnik etc don’t need a diluent. https://cdc.gov/vaccines/covid-19/info-by-product/pfizer/index.html…

Transportation While the cold transport box looks small, they are heavy (~38kg). Each refrigerated truck holds about 65 boxes, or about 3.2 lakh doses. Pallets cannot be left unattended & must be moved to ULT storage quickly. Boxes must be returned. https://fiercepharma.com/manufacturing/pfizer-designed-new-container-and-plans-to-tap-shipping-companies-for-covid-19…

Transport by air is restricted in volume by FAA guidelines on dry ice transport. Current limit is 15000lb, which translates to at most 1 million doses per flight. This was after increasing from 3000lb. Not all jurisdictions did so: https://npr.org/2020/12/11/945670606/transporting-and-distributing-vaccines-will-be-unprecedented-logistical-operatio…

Typical air transport is only 3-5 lakh doses per flight. This is how much Japan and Israel get per delivery, since not all countries allow much dry ice transport, which poses a cabin pressure risk from dry ice sublimation. https://asia.nikkei.com/Spotlight/Coronavirus/Japan-receives-2nd-shipment-of-Pfizer-vaccine… https://healthcareitnews.com/news/emea/israel-share-data-pfizer-exchange-covid-19-vaccine-doses…

In effect a plane carries about as much as a freezer trailer truck. This means any place served by air will be significantly costlier per dose, and will lack ability to scale, This is why Pfizer orders have been focused on N.America and EU/UK - local mfg + truck delivery.

This won’t work with India. Pfizer's 2021 goal is 2.5 billion doses, but most are already reserved. Any availability will not only take time, but will be far too few, delivered too intermittently at too high cost to have an impact. Cost discussed further.. Price Pfizer discourages disclosure of prices. While US and EU order prices are known, most others are not. The Japanese PM declined to answer. Israel prices were found to be $47/dose (Rs.3500) after a parliamentary inquiry: https://timesofisrael.com/israel-said-to-be-paying-average-of-47-per-person-for-pfizer-moderna-vaccines/…

Pfizer has manufacturing plants in USA & Belgium. US/Canada/EU deliveries can be trucked cheaply given that a truck and plane carry the same 3-4L doses. Countries dependent on air freight pay much more - data shows this. US $19.50 price was only for the first 100m doses.

Pfizer renegotiates prices per order and has stalled deliveries until new orders are paid. Anyone negotiating with Pfizer will need leverage. Small volume private orders will likely be more than $50 given govts are paying close to that much. https://jpost.com/breaking-news/banana-republic-pfizer-outraged-israel-failed-to-pay-for-covid-vaccines-664140…

At current production volume, Pfizer cannot supply more than 3% of weekly vaccination rate in India recently, even with weekly 5L shipments like Israel. This supply will cost 8-10x of Indian options, not counting additional ULT infrastructure capital and operating costs.

Pfizer only makes sense to some private entities willing to invest in ULT infrastructure and have clientele who can afford above Rs.3500/dose. In terms of value for money, it makes no sense at all as an option for government procurement. Too costly, low volume.

An army moves on its stomach. Pfizer moves on its ULT cold chain combined with very narrow logistics channels for countries where supplies cannot be trucked to destination in a week or less. This makes the Pfizer vaccine a niche product as far as India is concerned

An army moves on its stomach. Pfizer moves on its ULT cold chain combined with very narrow logistics channels for countries where supplies cannot be trucked to destination in a week or less. This makes the Pfizer vaccine a niche product as far as India is concerned

OTOH, Covaxin cost a fraction of Pfizer and can do normal fridge temp (2 to 8C). India has existing vaccine cold chain for this requirement. Covaxin production rate (20m/month) is almost 10x Pfizer delivery rate to Israel/Japan, and will increase further by summer.

The only viable option where Pfizer makes sense to India is local production, combined with TRIPS waiver enabling duplication of raw material (e.g. lipid nanoparticles) locally. This would bridge price gap to only a few multiples, rather than over 10x as is the case now.

Pfizer cannot deliver any significant volume to India and won’t be remotely cost competitive today. They would be best served by leveraging the PLI scheme to set up vaccine production in India as an FDI investment, enabling investment in ULT trucking and storage

Pfizer’s current ULT air freight infrastructure makes it too expensive. No bridging trial data on efficacy vs current dominant local strains is a critical problem in the middle of this wave. This makes even the value of such a premium a questionable proposition today.

Hmm, I think it has more to do with cases being manageable and prudency to wait for evidence...kinda risky but island population genetics are a bit different. Japanese also beleive in "tough it out" mindset lol but Chinese virus one upped everyone

 

[omaebakabaka]

So something like this? https://www.nature.com/articles/s41586-020-03065-y

Yes, goal of the enemy is not to kill instantly as that would be somewhat purposeless but to cause massive penality like extended hospital stays, secondary lingering infections during and post recovery and stressign the system to extremes and impact damage on economy and political and every other aspect of soverignity.

This is worse than nuclear attack

 

[tarunraju]

How would that even work? What trait of "Indian genetics" will the virus target. Not dismissive of your assertion, just genuinely curious.

Bad news: Creating "race specific" viruses isn't science-fiction anymore. Every race is genotyped. The designer just needs to figure out what markers to use.

Good news: As of today, it is not beyond India's capability to come up with an NCoV that targets Hans or Caucasians. It's just a question of conviction for Government of India: Has it seen evidence of b.1.617 being an unnatural "mutation"? Is it convinced that it was a bioweapon? Did it study enough CCTV footage to see "municipal workers" spraying insecticide-looking aerosol in our cities who don't tally with the payrolls of those Municipal Corporations or their contractors/subcontractors? And lastly, does Modi have the balls to retaliate? If the answers to all these questions is a yes, then Indian scientists can create an NCoV that eradicates a double-digit percentage of China's population within weeks. It's within our capability.

India's expertise in the biotech/pharmaceutical/genetics/mol-bio domains is vastly underestimated globally. It took us no time to create Covaxin. We're only limited in scale, but not in our ability.

 

[Lost user]

Summary of this video:

The Indian Consul-General in Hong Kong asked the Chinese government to intervene and regulate prices of COVID-related supplies (such as O2 Concentrators). Someone asked chicom gobbels Hua Chunying about this.

She said "yes, all parties should work toward an open global supply chain."

And now the real translation: "Remove all the trade embargoes you placed on Chinese products since Galwan, and we'll think about regulating prices of COVID supplies."

Also, Supply Chain resilience initiative of India, Japan, Australia...

 

[Lost user]

I am starting to believe this new strain is released as hit to impact Modi govt targeted towards Indian genetics, it is not spreading anywhere yet even after weeks

It's spreading in Nepal and UK.. Although since most adults in UK over 45 are vaccinated the impact might be limited.

 

[Lost user]

Tiny Singapore has sent 46 cryogenic containers with not much fanfare, unlike the US whose help is more hot air than anything else..

Singapore Extends Support To India Amid Rising Oxygen Crisis, Provides Cryogenic Tanks

India procured 46 cryogenic or ISO containers from Singapore to enhance the liquid oxygen supplies to various parts of the country.

thelogicalindian.com

 

[omaebakabaka]

It's spreading in Nepal and UK.. Although since most adults in UK over 45 are vaccinated the impact might be limited.

Nepal is South Asian and UK is well mini bangla and other stans....interesting to see who gets impacted more in UK race wise

 

[Okabe Rintarou]

I am starting to believe this new strain is released as hit to impact Modi govt targeted towards Indian genetics, it is not spreading anywhere yet even after weeks

Bad news: Creating "race specific" viruses isn't science-fiction anymore. Every race is genotyped. The designer just needs to figure out what markers to use.

Good news: As of today, it is not beyond India's capability to come up with an NCoV that targets Hans or Caucasians. It's just a question of conviction for Government of India: Has it seen evidence of b.1.617 being an unnatural "mutation"? Is it convinced that it was a bioweapon? Did it study enough CCTV footage to see "municipal workers" spraying insecticide-looking aerosol in our cities who don't tally with the payrolls of those Municipal Corporations or their contractors/subcontractors? And lastly, does Modi have the balls to retaliate? If the answers to all these questions is a yes, then Indian scientists can create an NCoV that can eradicate a double-digit percentage of China's population within weeks. It's within our capability.

In the B1.617 variant (the so-called "Indian" variant of Wuhan virus), two of the three major mutations are unique to this variant. The two unique mutations are P681R and E484Q. The L452R mutation is also found in the American variants (B.1.429 and B.1.427) of Wuhan virus.

The E484Q mutation seems structurally very close to the E484K mutation (which is found in South African B.1.351 variant, Japanese/Brazillian P.1 variant, UK/Nigerian B.1.525 variant and UK/USA B.1.1.7 variant). To complicate things, some B1.617 "Indian" sub-variants have the E484K instead of the E484Q mutation.

The P681R also has a close cousin mutation called P681H. P681H is found in UK variant B.1.1.7 and Nigeria variant B.1.1.207. Structural difference between these two also doesn't appear to be too great.

I am looking at the structural differences from a chemical standpoint, not taking into account the biological aspects. That said, most of these mutations are caused by amino acids that are commonly found in human body.

If there is a chance of B1.617 being a bioengineered variant meant to target the Indian genome-type, there has to be a unique mutation meant to target Indian genome. In the B1.617 variants, we haven't seen that yet.

 

[omaebakabaka]

In the B1.617 variant (the so-called "Indian" variant of Wuhan virus), two of the three major mutations are unique to this variant. The two unique mutations are P681R and E484Q. The L452R mutation is also found in the American variants (B.1.429 and B.1.427) of Wuhan virus.

The E484Q mutation seems structurally very close to the E484K mutation (which is found in South African B.1.351 variant, Japanese/Brazillian P.1 variant, UK/Nigerian B.1.525 variant and UK/USA B.1.1.7 variant). To complicate things, some B1.617 "Indian" sub-variants have the E484K instead of the E484Q mutation.

The P681R also has a close cousin mutation called P681H. P681H is found in UK variant B.1.1.7 and Nigeria variant B.1.1.207. Structural difference between these two also doesn't appear to be too great.

I am looking at the structural differences from a chemical standpoint, not taking into account the biological aspects. That said, most of these mutations are caused by amino acids that are commonly found in human body.

If there is a chance of B1.617 being a bioengineered variant meant to target the Indian genome-type, there has to be a unique mutation meant to target Indian genome. In the B1.617 variants, we haven't seen that yet.

That is the thing, this is similar to doping....one can get away if you are the first in market before someone else understands and discovers what may be going on.....this whole thing is still considered naturally induced from animals. This is why India can't just sitback and pursue derived much less 2nd or 3rd derivative research of stuff....I do not trust many of publicationseither knowing university politics and what not. All systems are currently running on very low trust environment and objectivity is next to non existent

 

[Okabe Rintarou]

That is the thing, this is similar to doping....one can get away if you are the first in market before someone else understands and discovers what may be going on.....this whole thing is still considered naturally induced from animals. This is why India can't just sitback and pursue derived much less 2nd or 3rd derivative research of stuff....I do not trust many of publicationseither knowing university politics and what not. All systems are currently running on very low trust environment and objectivity is next to non existent

Agreed that the research out of universities could be motivated. But GoI is conducting its own internal enquiry into the nature and structure of the mutations and so far they have identified only these three mutations as major mutations and all three of these mutations (or similar mutations) were discovered in variants in the rest of the world first before the B1.617 "Indian" variant was discovered. This is why I am considering the likelihood of B1.617 being a variant engineered to target Indian genome to be very low.

GoI is itself investigating the matter. Lets see what comes out. All I hope for is that GoI doesn't try to brush under the rug whatever it finds.

 

[Deadtrap]

India to have over 2 billion vaccine doses during August-December, enough for all: Centre | India News - Times of India

NEW DELHI: The Centre on Thursday said that over two billion doses of Covid vaccines will be available in India between August and December this year which will be sufficient to vaccinate the entire population.
The assurance from the Centre comes as several states are grappling with a shortage of vaccines, which has slowed down the nationwide immunisation programme.
In a media briefing, Niti Aayog member VK Paul said that more Covid vaccines will be available in the near future besides the ones that are already in use.

"Two billion doses (216 crore) will be made in the country in five months for India and for people of India. Vaccine will be available for all as we move forward," Paul said.
He added that by the first quarter of the next year, this number is likely to be three billion.
Paul estimated that between August and December, nearly 75 crore doses of Covishield and 55 core doses of Covaxin will be made available.

Coronavirus vaccine news: India to have over 2 billion vaccine doses during August-December, enough for all: Centre | India News - Times of India

India News: The Centre on Thursday said that over two billion doses of Covid vaccines will be available in India between August and December this year which will

timesofindia.indiatimes.com

all vaccine manufactureres should be under strict watch and protection to prevent sabotage from china and chinese proxies in India

If Govt pull this off then the Brand ‘Modi’ and ‘New India’ will be restored to good level after taking a massive hit post second wave. All Western Regime change media can fuck themselves then. Finger crossed.

 

[omaebakabaka]

Agreed that the research out of universities could be motivated. But GoI is conducting its own internal enquiry into the nature and structure of the mutations and so far they have identified only these three mutations as major mutations and all three of these mutations (or similar mutations) were discovered in variants in the rest of the world first before the B1.617 "Indian" variant was discovered. This is why I am considering the likelihood of B1.617 being a variant engineered to target Indian genome to be very low.

GoI is itself investigating the matter. Lets see what comes out. All I hope for is that GoI doesn't try to brush under the rug whatever it finds.

Perhaps, it is just a mutation caused by the inherent chronic conditions seen in Indian environments like hygiene and also disease traits such as diabetes, smoking, tobacco chewing and obesity and what not. I wont consider India as leader in genetics or isolation or skills to do that level of 1st to market especially when it has possibilities of being a bio weapon origin....so GOI has limits in my opinion

 

[sorcerer]

If Govt pull this off then the Brand ‘Modi’ and ‘New India’ will be restored to good level after taking a massive hit post second wave. All Western Regime change media can fuck themselves then. Finger crossed.

well..need to keep china and US at bay..cuz they have a way of throwing hurdles in between.
This epidemic showed us who the friends are and who the foes are.

 

[afako]

The countries who projected Corona porn on India. Now their turn.

 

[Spindrift]

Yes, China created a virus to attack Wuhan first. People believe in all kinds of conspiracy BS these days

Well, if one looks at the history of the CCP, it as never hesitated to kill it's own people.

 

[Tactical Doge]

Y'all Nibbiars
Mother turned out to be a vaccine denier, I myself registered for vaccine, but she's hell bent on not getting the vaccine
Argument: she's allergic to different stuff
Apparently she's been watching too much YouTube in which * experts * dissect stuff

She refuses even to meet a doctor for professional advice, what to do, hai bhagwan