Wuhan Coronavirus Thread

Is coronavirus a biological warfare agent released by China?

  • yes

    Votes: 105 91.3%
  • no

    Votes: 10 8.7%

  • Total voters
    115

sajobajo

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There are too many unknowns about efficacy of any known vaccine against this fast mutating virus.
Yes, just saying that we shouldnt be holding pfizer on its alleged vaunted pole without having them conduct immunogenicity trials. Could be no better or worse than Sinopharm's vaccine in terms of real world performance.
 

sajobajo

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Bengaluru positivity rate hits 55%
more chances of herd immunity than getting vaccinated these days...
If only 10 symptomatic patients are sent for testing, a good chance that half of them are +ve, with positivity ratio at 50%. Doesnt mean the remaining 90 people who reside in the area infected. To bring positivity ratio down all we need to do is send 50 other random people for testing. But right now we dont want to overburden the system and reserve the testing for those who truly need it.
Herd immunity out of infection recovery is too big a risk for lives, with the havoc it is playing with even young lives like Shri Vikram Sampath.



PS : Rajan Nikhalje, ie, Chota Rajan, a one time asset for India and has eliminated many Dawoodi gangbangers for killing innocent Hindus via terror attacks, has succumbed to COVID in AIIMS. Om Shanti.
 

ladder

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Not CIA.... those are facts Per se... It's a utter failure of whole system....

Govt aside, politicians are busy doing politics on people's corpses and those on ground busy collecting papers bills .. corruption is what ails us... be it govt or people...

As for Pvt vaccination centres goes, they are deliberately pilgrimaging vaccines doses to Pvt sector...to earn those 1200 re... and covaxin is primary target...

Cowin do not work...the hospital which jabbed me is yet to get cowin working..and they say they have no clues when it will work...i am hoping that certificate issued by hospital with vaccine bill will help me get second dose...

no body to be blamed...we all are naked in centre...
Co-win not working? Yesterday somebody I know got jabbed and 2 hours later got SMS containing the link to download the certificate.
 

SKC

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Bengaluru positivity rate hits 55%
more chances of herd immunity than getting vaccinated these days...
Sero tests have been joke for country like India.
They are taking sample of 100 people for city like Varanasi and declaring pandemic situation everywhere.
Similarly last year for NCR they took 550 samples and declared that 70% already infected in whole NCR.
 

Kumata

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Co-win not working? Yesterday somebody I know got jabbed and 2 hours later got SMS containing the link to download the certificate.
Yeah.. apparently they particular hospital have some issues with portal specifically.. I raised it with hospital again today and they said speak to people managing COWIN, we cannot do anything and do what ever u want to do..

Tried speaking to 1075 and Delhi vaccine helpline... there people are more frustrated with Cowin portal and niggling issues... still lady said, I shud wait for 3-4 days .. hospital will update the status once issues are resolved....

hoping they will resolve in 2-3 days.. looking back.. going to a pvt centre was a mistake...
 

SKC

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Just returned home after getting my First shot of Covaxin.

Had booked a Sarkari School center in North Delhi for the shot. Already few friends had got shot from such school turned into center.
I must say the center was very well managed. Smooth process overall. No rush in the center as the Covaxin slots are only 50-150 per center each day.
I got my no the moment I reached the center and got the jab immediately.

My cousin also had jab in school center in the morning in Delhi. his was for covieshield. The covieshield slots were 700 for that school for the day but still there was no rush and he got his jab within 10 min of reaching there.

I would suggest all to look for and book Sarkari centers like CHC, PHC, Schools and Few Gov Hospital only for private book for big names like fortis and Max.

I got the message to download the certificate just 5 min after getting the Jab.
 

angryIndian

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Modi presses ahead with $1.8 billion parliament renovation even as Covid-19 ravages India
1620390535035.png


 
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Modi presses ahead with $1.8 billion parliament renovation even as Covid-19 ravages India
View attachment 88467

Issue with oxygen wasn't financial but logistical and hence project doesn't come at cost of healthcare.

Also, Central Vista project had been awarded before the current pandemic situation. Not only the pulling out would cause cost overruns while wasting already invested money, contractors and workers will lose their jobs dragging government into court.

Project can be opposed on grounds of populism but anyone opposing on interlink to pandemic situation is ill informed or stupid at best.
 

ladder

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Both jabs of pfizer taken, still covid won..

Renowned infectious diseases expert Dr Rajendra Kapila, 81, dies of Covid-19


“For the last one year I have been working at a Covid-19 lab in New Jersey and had ensured a safe environment at home,” said Dr Deepti, who specialises in microbiology. “It is ironic that we came to India for two weeks and he contracted it here.”

She said Dr Kapila had got both doses of the Pfizer vaccine in the US.
There is some commentary on this incident in BRF Coronavirus thread, I tend to agree with it.
You can read those and share your views here if you have certain other view regarding the incident.
 

Okabe Rintarou

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Issue with oxygen wasn't financial but logistical and hence project doesn't come at cost of healthcare.

Also, Central Vista project had been awarded before the current pandemic situation. Not only the pulling out would cause cost overruns while wasting already invested money, contractors and workers will lose their jobs dragging government into court.

Project can be opposed on grounds of populism but anyone opposing on interlink to pandemic situation is ill informed or stupid at best.
Most people don't have the concept of sunk costs, contractual obligations, cost of long lead time acquisitions and surveys. They think such projects can be stopped since "ahbi start nahi kiya banana". No concept of scheduling at all.

______________________________________________________________________________________

Anyways.
 

angryIndian

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Issue with oxygen wasn't financial but logistical and hence project doesn't come at cost of healthcare.
I am well aware that Oxygen procurement was a logistical issue. This should have been sorted out well in advance. Anyone who has studied epidemics of history, they would realize that pandemic strikes in waves. The government should have taken advantage of the lull period of the entire second half of last year to prepare for all eventualities of the future. Strangely the government did absolutely nothing apart from electioneering and as a consequence is now struggling to contain the surge.


If people are dying from a lack of primary care, then this points to nothing but a criminal negligence on part of the government.





Also, Central Vista project had been awarded before the current pandemic situation. Not only the pulling out would cause cost overruns while wasting already invested money, contractors and workers will lose their jobs dragging government into court.
At a time when the country is facing it's biggest threat since independence, would it be wise enough to go ahead with the central vista project ?
I rather see few thousands loose their jobs and money than see hundreds of thousands or millions loosing their lives.

This current wave has not even subsided and there is a danger of an even more dangerous wave on anvil.
The government should utilize all it's resources towards combating this.
 

johnq

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TND EXCLUSIVE: Classified study found COVID-19 could have originated in Chinese lab
A classified study of the origin of SARS-CoV-2 conducted a year ago by scientists at the Lawrence Livermore National Laboratory, the Department of Energy’s premier biodefense research institution, concluded the novel coronavirus at the heart of the current pandemic may have originated in a laboratory in China, Sinclair has learned. Read more: https://wjla.com/news/nation-world/ex...
 

Okabe Rintarou

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Related to the deadly Black Fungus "Mucormycosis" that is affecting patients after Covid-19 (also related to dexamethasone dosage):-

While our country battles with COVID-19, the issue of post COVID-19 sepsis has emerged as a significant problem. India bears the dubious distinction of being both the diabetes, as well as the mucormycosis, ‘capital’ of the world. COVID-19 and its treatment, against this backdrop, amounts to a recipe for disaster.
With an estimated 77 million cases in the adult population, diabetes is India’s fastest growing epidemic. A recent cross-sectional study from all states of India, revealed that 47% of Indians are unaware of their diabetic status and only a quarter of all patients achieved adequate glycemic control on treatment.1 The unholy association between diabetes and the severity of SARS-CoV-2 infection has been repeatedly established in various studies from across the world.2
Mucormycosis sometimes appears as the diabetes-defining illness, and remains one of the most devastating complications in uncontrolled diabetics with mortality rates ranging between 40-80%. India contributes to 40% of the global burden of this “rare mould” infection as it is called in western literature, with an estimated prevalence of 140 cases per million population.3
Post COVID-19 sepsis is what occurs after SARS- CoV-2 has had a rampage in the human body and we are literally left picking up the pieces. It leads to a dysregulated innate immune response, ciliary dysfunction, cytokine storm, thrombo-inflammation, microvascular coagulation and eventual immune exhaustion. This cascade of events facilitates secondary bacterial and fungal infections especially in critically ill patients subjected to emergency invasive procedures, mechanical ventilation, CRRT, ECMO, poor nursing ratios, prolonged hospital stays and breaches in asepsis. Further, the use of corticosteroid treatment and anti-IL-6-directed strategies in these highly susceptible hosts along with high fungal spore counts in the environment creates the perfect setting for mould infections.
While COVID-19-associated pulmonary aspergillosis (CAPA) has received much international attention, the Indian epidemiology of invasive mould infections in the ICU reveals a significant burden of invasive mucormycosis.4 This has recently emerged as a life threatening complication of COVID-19 in our country. Although the predisposing factors and pathogenesis are somewhat similar to that of other mould infections, certain unique characteristics and key distinguishing factors must be kept in mind in order to promptly suspect the infection, confirm the diagnosis and offer timely therapeutic intervention.
Mucorales are ubiquitous moulds, abundantly found in the environment on decaying organic matter. Various studies from hospitals across the country have revealed heavy mould spore counts even in hospital air due to predominantly hot, humid conditions in our tropical climate.5
Unlike CAPA, invasive mucormycosis has been observed even in patients with mild to moderate SARS- CoV-2 infections. The strongest predisposing factor appears to be hyperglycemia in undiagnosed or uncontrolled diabetics. Hyperglycemia leads to increased expression of the endothelial receptor GRP78, resulting in polymorphonuclear dysfunction, impaired chemotaxis and defective intracellular killing. An important virulence trait of Mucorales is the ability to acquire iron from the host which is an essential element for its growth. In conditions of ketoacidosis, free iron becomes readily available in the serum. This excess endogenous iron is efficiently taken up by the Mucorales through siderophores or iron permeases, further enhancing their virulence. These effects are greatly amplified by the use of corticosteroids and immunosuppressants in susceptible hosts. Corticosteroids themselves cause impairment in the neutrophil migration, ingestion, and phagolysosome fusion. Coupled with the potential implications of steroid-induced hyperglycemia, the diabetic COVID 19 patient receiving corticosteroids or other immunosuppressants is exceptionally vulnerable to the development of mucormycosis.6,7
The landmark RECOVERY trial published in June 2020 has served as a ‘license’ to use steroids in patients with COVID-19. However, the fine print clearly revealed some important messages that we seem to have overlooked. Benefit was specifically shown with low dose, short duration dexamethasone in moderate to severe illness. Although, higher doses and longer durations may be used in exceptional cases due to compelling reasons, such patients should be evaluated for undiagnosed diabetes, checked for strict glycemic control and closely monitored for secondary infections. A cavalier attitude to the use of steroids should be discouraged at all costs.
The two most important manifestations of Mucormycosis in this setting are rhino-orbital-cerebral and pulmonary. Suspicion is based on subtle clinical and imaging clues, risk factors and disease development or progression while on any antibacterial or antifungal therapy that does not cover Mucor. Physicians need to have seen a ‘critical’ number of cases to recognize the signature of Mucor.
The clinical hallmark is tissue necrosis manifested as a necrotic lesion, eschar or black discharge in the nasal or oral cavity. Orbital, ocular and cranial nerve involvement are ominous signs that must be taken seriously. Alternative erroneous diagnoses lead to antibacterial and further steroid use which add fuel to the fire. Pulmonary Mucormycosis has certain radiologic findings which help to distinguish it from Aspergillosis. There is no biomarker for mucormycosis and hence a negative galactomannan and beta-d-glucan are useful pointers to rule out other mould infections. A false positive galactomannan due to generic piperacillin tazobactam use etc. can lead to the erroneous diagnosis of invasive aspergillosis. Although challenging, the need to distinguish Mucor from bacterial infections and from aspergillosis in a timely fashion is of essence. Treatment with voriconazole for suspected invasive aspergillosis increases the pathogenicity of Mucor with obvious dire consequences.
Rapid diagnostic methods include biopsy, KOH mount and Calcofluor stain. Mucor is difficult to routinely culture. Biopsy remains the mainstay of diagnosis and the benefits of the procedure outweigh the risk, even in a ‘difficult to access’ location or in the presence of coagulopathy.
Treatment principles include antifungal agents, surgical debridement, reversal of underlying predisposing factors and adjuvant therapy. Amphotericin B has been the standard of treatment for invasive mucormycosis. COVID-19 patients may have developed acute on chronic renal failure which may be mitigated by switching to a less- or non-nephrotoxic alternative. Therefore Posaconazole or Isavuconazole may have to be used. The latter has the added advantage of shortening the QT interval which may have been affected by HCQ, Azithromycin which many patients still continue to receive. Surgical debridement, the earlier the better, is pivotal in the management of mucormycosis. The optimal time of surgery to reduce the operative risk to the patient with COVID-19 and the risk of transmission to the operating team is a contentious issue. Replication competent virus has not been recovered from patients with mild to moderate illness after ten days, from patients with severe illness after fifteen days or from any critically ill patient after twenty days.8
Adjuvant therapy with caspofungin, deferasirox, statins, aspirin, and hyperbaric oxygen may have to be considered. Mucormycosis needs to be actively managed by a team which includes members from almost all departments in the hospital. Therapy is toxic and very resource intensive. In a recent Indian study, 24.3% patients left the hospital against medical advice due to the anticipated cost, morbidity of surgery and prognosis.9
Mucormycosis developing in the post COVID-19 setting ‘breaks the back’ of a patient’s family that is barely recovering from a treacherous viral infection. This scenario is nothing short of ‘RECOVERY from the frying pan and into the fire.’


Source: https://www.japi.org/x27464c4/post-covid-19-mucormycosis-from-the-frying-pan-into-the-fire

EDIT: More information- https://www.cdc.gov/fungal/diseases/mucormycosis/causes.html

I am well aware that Oxygen procurement was a logistical issue. This should have been sorted out well in advance. Anyone who has studied epidemics of history, they would realize that pandemic strikes in waves. The government should have taken advantage of the lull period of the entire second half of last year to prepare for all eventualities of the future. Strangely the government did absolutely nothing apart from electioneering and as a consequence is now struggling to contain the surge.


If people are dying from a lack of primary care, then this points to nothing but a criminal negligence on part of the government.







At a time when the country is facing it's biggest threat since independence, would it be wise enough to go ahead with the central vista project ?
I rather see few thousands loose their jobs and money than see hundreds of thousands or millions loosing their lives.

This current wave has not even subsided and there is a danger of an even more dangerous wave on anvil.
The government should utilize all it's resources towards combating this.
Don't you get tired of doing all this Bull$hit, peddling your propaganda everyday like a bot? Be a human, for once. Instead of blaming the government and running your political agenda, find some time to actually understand the bloody disease and share some information about it on this forum so that it benefits everyone, including yourself.
 

Okabe Rintarou

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