Ancient Period
The region was among the earliest in the world to see human habitation, agricultural communities and civilization. During the Bronze Age, independent Canaanite city-states were established, and were influenced by the surrounding civilizations of ancient Egypt, Mesopotamia, Phoenicia, Minoan Crete, and Syria. Between 1550–1400 BCE, the Canaanite cities became vassals to the Egyptian New Kingdom who held power until the 1178 BCE Battle of Djahy (Canaan) during the wider Bronze Age collapse. The Philistines arrived and mingled with the local population, and according to Biblical tradition, the United Kingdom of Israel was established in 1020 BCE and split within a century to form the northern Kingdom of Israel, and the southern Kingdom of Judah. Modern archaeologists dispute parts of the Biblical tradition, the latest thinking being that the Israelites emerged from a dramatic social transformation that took place in the people of the central hill country of Canaan around 1200 BCE, with no signs of violent invasion or even of peaceful infiltration of a clearly defined ethnic group from elsewhere.
The region became part of the Neo-Assyrian Empire from c.740 BCE, which was itself replaced by the Neo-Babylonian Empire in c.627 BCE. According to the Bible, a war with Egypt culminated in 586 BCE when Jerusalem was destroyed by the Babylonian king Nebuchadnezzar II and the local leaders of the region of Judea were deported to Babylonia. In 539 BCE, the Babylonian empire was replaced by the Achaemenid Empire. According to the Bible and implications from the Cyrus Cylinder, the exiled population of Judea was allowed to return to Jerusalem.
In the 330s BCE, Macedonian ruler Alexander the Great conquered the region, which changed hands several times during the wars of the Diadochi and later Syrian Wars. It ultimately fell to the Seleucid Empire between 219–200 BCE. In 116 BCE, a Seleucid civil war resulted in the independence of certain regions including the Hasmonean principality in the Judean Mountains. From 110 BCE, the Hasmoneans extended their authority over much of Palestine, creating a Judean-Samaritan-Idumaean-Ituraean-Galilean alliance. The Judean (Jewish, see Ioudaioi) control over the wider region resulted in it also becoming known as Judaea, a term that had previously only referred to the smaller region of the Judean Mountains. Between 73–63 BCE, the Roman Republic extended its influence into the region in the Third Mithridatic War, conquering Judea in 63 BCE, and splitting the former Hasmonean Kingdom into five districts. The three-year Ministry of Jesus, culminating in his crucifixion, is estimated to have occurred from 28–30 CE, although the historicity of Jesus is disputed by a minority of scholars. In 70 CE, Titus sacked Jerusalem, resulting in the dispersal of the city's Jews and Christians to Yavne and Pella. In 132 CE, Hadrian joined the province of Iudaea with Galilee to form new province of Syria Palaestina, and Jerusalem was renamed "Aelia Capitolina". Between 259–272, the region fell under the rule of Odaenathus as King of the Palmyrene Empire. Following the victory of Christian emperor Constantine in the Civil Wars of the Tetrarchy, the Christianization of the Roman Empire began, and in 326, Constantine's mother Saint Helena visited Jerusalem and began the construction of churches and shrines. Palestine became a center of Christianity, attracting numerous monks and religious scholars. The Samaritan Revolts during this period caused their near extinction. In 614 CE, Palestine was annexed by another Persian dynasty; the Sassanids, until returning to Byzantine control in 628 CE.
Middle Ages
Palestine was conquered by the Islamic Empire, beginning in 634 CE. In 636 CE, the Battle of Yarmouk during the Muslim conquest of Syria symbolized the complete Muslim takeover of the region, which was regarded as Bilad a-Sham (Greater Syria). The word 'Arab' at the time referred to Bedouin nomads with an Arabian ancestry. The local population engaged in farming, which was considered demeaning, were called Nabaț, referring to Aramaic-speaking villagers. A ḥadīth, brought in the name of a Muslim freedman who settled in Palestine ordered them not to settle in the villages, for he who abides in villages it is as if he abides in graves. In 661 CE, with the assassination of Ali, Muawiyah I became the uncontested Caliph of the Islamic World after being crowned in Jerusalem. The Dome of the Rock, completed in 691, was the world's first great work of Islamic architecture.The Umayyad were replaced by the Abbasids in 750. Ramla, the major city, became the administrative centre for the following centuries. Tiberias became a thriving centre of Muslim scholarship.From 878, Palestine was ruled from Egypt by semi-autonomous rulers for almost a century, beginning with the Turkish freeman Ahmad ibn Tulun, for whom both Jews and Christians prayed when he lay dying and ending with the Ikhshidid rulers, characterized by persecution of Christians as the threat from Byzantium grew.The Fatimids, with a predominantly Berber army, invaded the region in 970, a date that marks the beginning of a period of unceasing warfare between numerous enemies, which destroyed Palestine, and in particular devastating its Jewish population.In 1073, Palestine was captured by the Great Seljuq Empire, only to be recaptured by the Fatimids in 1098, who then lost the region to the Crusaders in 1099. Their control of Jerusalem and most of Palestine lasted almost a century until defeat by Saladin's forces in 1187, after which most of Palestine was controlled by the Ayyubids. A rump crusader state in the northern coastal cities survived for another century, but, despite seven further crusades, the crusaders were no longer a significant power in the region. The Fourth Crusade led directly to the decline of the Byzantine Empire, dramatically reducing Christian influence throughout the region.
The Mamluk Sultanate was indirectly created in Egypt as a result of the Seventh Crusade. The Mongol Empire reached Palestine for the first time in 1260, beginning with the Mongol raids into Palestine under Nestorian Christian general Kitbuqa, and reaching an apex at the pivotal Battle of Ain Jalut. In 1486, hostilities broke out between the Mamluks and the Ottoman Turks in a battle for control over western Asia, and the Ottomans captured Palestine in 1516.