Who would win a battle between the 2 most powerful rulers of early 16th century South Asia who were also some of the most powerful rulers in the world in the 16th century. Both rulers ruled during the same period in the early 16th century. Krishnadevaraya (1471-1529) was the greatest ruler of the Vijayanagar Empire in southern India. Babur (1483-1530) was the founder of the Mughal Empire of north India. Both rulers not only used powerful medieval weapons but they even had access to cannons and guns.